For Animal Health Only

ESTROPUR

Solution for Injection

COMPOSITION:

ESTROPURis a transparent, clear, colorless ready-to-use solution containing 0.075 mg per ml.

Contains R (D, +) Cloprostenol sodium salt and 1 mg Chlorocresol.

SPECIAL CLINICAL INFORMATION AND SPECIAL WARNINGS FOR TARGET SPECIES

• In order for prostaglandins to be effective, there must be a luteal structure in the ovary.

• Animals must have normal cycles for successful synchronization and cycle control.

• In the refractory period lasting 4-5 days after ovulation, prostaglandins are ineffective.

• Mares must be in true oestrus for the desired effect to be seen, cysts in their uterus

or in the presence of neoplasm cases, no response may be obtained from prostaglandin applications.

• It is necessary to define well the cyst structure formed in the ovary, prostaglandins in follicular cyst

the desired response is not received. Luteal cysts are successfully treated.

The general condition of the animals to which prostaglandin will be applied is correct and mineral matter.

have no shortcomings; If there are, take care to correct these conditions first.

should be displayed.

The rectal examination to be performed before the drug is administered is very important for the correct diagnosis and application. In this way, the risk of insemination of animals in anoestrus and pregnant animals is eliminated.

• Giving out some of the drug or giving it to the fat tissue during the injection may cause the desired result not to be obtained.

USE DURING PREGNANCY AND LACTATION

The preparation is designed to cause the elimination of the hormonal mechanism that maintains the pregnancy of pregnant animals and thus gives birth. It should not be administered to pregnant animals except in cases of terminating an unwanted pregnancy or initiating a controlled birth.

UNDESIRED/SIDE EFFECTS

Heat irregularities, abdominal pain and diarrhea can be seen in mares.

DRUG INTERACTIONS

The expected effect of ESTROPUR may be reduced when used with steroid or nonsteroidal anti-inflammatory drugs that inhibit endogenous prostaglandin synthesis.

SYMPTOMS OF OVERDOSE, PRECAUTIONS AND ANTIDOTE

ESTROPURIt has been tested for evaluation of possible side effects on the animal organism, acute toxicity and determination of tolerance. When examining the tolerance of the tested preparation, no general or local changes were found in the genital organs of the lactating cow by clinical examination.

There was no negative cloprostenol sodium salt effect in lactating cows when ten times the dose was administered within 10 days. The increase in heart rate is temporary. Biochemical indicators did not change significantly during the experiment.

WARNINGS ABOUT DRUG RESIDUES IN FOOD

Drug residue washout time (withdrawal); During the treatment and after the last drug administration, cattle should not be sent to slaughter before 1 day has passed. The residual purification period for milk is 0 days.

GENERAL WARNINGS

- _cc781905-5cde-3194-bb3b-136bad-136bad5cf3b-13659c133655cc-bb3b-fbc-136bad5cf1365cf583153594cc781905-5cde-3194-bb3b-136bad-136bad5cf136558d_583136359cc7819055cf78359cc781905cc78d359cc781905 -5cde-3194-bb3b-136bad5cf58d_ _cc781905-5cde-3194-bb3b-136ba5cf58d_ Consult your veterinarian before use and any unexpected effects

- _cc781905-5cde-3194-bb3b-136bad-136bad5cf3b-13659c133655cc-bb3b-fbc-136bad5cf1365cf583153594cc781905-5cde-3194-bb3b-136bad-136bad5cf136558d_583136359cc7819055cf78359cc781905cc78d359cc781905 -5cde-3194-bb3b-136bad5cf58d_ Keep out of the reach of children and away from foodstuffs.

- _cc781905-5cde-3194-bb3b-136bad-136bad5cf3b-13659c133655cc-bb3b-fbc-136bad5cf1365cf583153594cc781905-5cde-3194-bb3b-136bad-136bad5cf136558d_583136359cc7819055cf78359cc781905cc78d359cc781905 -5cde-3194-bb3b-136bad5cf58d_ Do not buy products with expired shelf life and do not use damaged packaging.

PRECAUTIONS TO BE TAKEN BY THE APPLICANT AND WARNINGS FOR PHYSICIANS

Prostaglandin can be absorbed through the skin, so especially women of childbearing age, pregnant women and asthmatics should be cautious in the use of this product. In case of accidental spillage on the skin, it should be washed off immediately with water.

Prostaglandins of the F2alpha type can cause bronchospasm in humans. In case of respiratory distress caused by accidental inhalation or injection, bronchodilators such as isoprenaline or salbutamol must be rapidly inhaled.

Estropur

It can also be used on ponies and donkeys, with target animal species being cows, mares and sows.
ESTROPURD (+) Cloprostenol sodium salt is a synthetic analogue of Prostaglandin F2α, which has been characterized by its local specific luteolytic effect in various animal species. R (D, +) and S enantiomers of cloprostenol have been produced synthetically.

R (D, +) cloprostenol is a biologically active substance. R (D, +) Cloprostenol sodium affects ovarian and uterine smooth muscles and causes luteolysis of the corpus luteum. Increases pregnant and non-pregnant uterine activity in most mammalian species. Its luteolytic activity is 200-400 times that of natural PGF2α.

The mechanism of action of R (D, +)   Cloprostenol sodium is similar to that of natural prostaglandin F2α produced by the uterus. R (D, +)   Cloprostenol sodium decreases the concentration of progesterone produced by the corpus luteum by abruptly lowering the LH receptors and causing uterine constriction in the corpus-ostrual ventricle. Performs flour luteolysis.

R (D, +)   Cloprostenol sodium has therapeutic effect in endometritis or pyometra. The principle of this effect; The onset of estrus by luteolysis is an increase in uterine motility, which, together with the mobilization of protective agents in the endometrium, causes expulsion of unwanted uterine contents.

R (D, +)   Cloprostenol sodium In cows, it significantly increases the plasma level of oxytocin, resulting in increased contraction of uterine smooth muscles. It is rapidly absorbed after intramuscular administration and reaches its maximum blood plasma concentration in a short time. It undergoes biotransformation in the liver and kidney and is excreted in feces and urine.

It causes a rapid decrease in progesterone level after its administration. 7-8 hours after administration, the progesterone concentration is only 50%, the concentration detected within 28-32 hours is not higher than 0.5 ng/ml. The 17 beta-estradiol concentration is the same as in the normal cycle.
In Cows and Heifers:

1.   _cc781905-5cde-3194-bb3b-136bad5cf-136bad5cf1365cf3593194-bb3b-136bad5cf1365cdebbcf5cf1365cf583194-cc781905-5cde-3194-bb3b-136bad5bb-136bad5cf1365c35931cc781905-5cf5831944_cc781905-5cde-3194-cc781905-5cde-3194. 136bad5cf58d_   Oestrus Provocation and Synchronization

2.   _cc781905-5cde-3194-bb3b-136bad5cf-136bad5cf5cf5cf583194-bb3b-136bad5bbcf1365c3593194-bb3b-136bad5bbcf1365c3593194 136bad5cf58d_   Treatment of Ovarian Functional Disorders

3.   _cc781905-5cde-3194-bb3b-136bad5cc-136bad5cf3b-136bad5cf5cf5cf583194-bb3b-136bad5bcf1365c3593194-bb3b-136bad5bbcf375c375378 136bad5cf58d_   Postpartum or post mating Anestrus

4.   _cc781905-5cde-3194-bb3b-136bad5cf-136bad5cf5cf5cf583194-bb3b-136bad5bbcf1365c3593194-bb3b-136bad5bb5cf1365c35931cc781905-5cde-3194-bb3b-136bad5bb-136bad5cf1365c35931-cc781905-5cde- 3194 136bad5cf58d_   Combined Treatment of Luteal Cysts and Follicular Cysts

5.   _cc781905-5cde-3194-bb3b-136bad5bb-136bad5cf1365c3593194-bb3b-136bad5bbcf1365c3593194-bb3b-136bad5cf5cf5cf359cf1365359378 136bad5cf58d_   Subestrus (latent or quiescent oestrus)

6.   _cc781905-5cde-3194-bb3b-136bad5bb-136bad5cf1365c3593194-bb3b-136bad5bbcf1365c3593194-bb3b-136bad5bb5cf1365cf3593194-bb3b-136bad5bb5cf1365c3593194 136bad5cf58d_   Birth Initiation

7.   _cc781905-5cde-3194-bb3b-136bad5cf-136bad5cf5cf5cf583194-bb3b-136bad5cf5cf5cf583194-bb3b-136bad5cf5cf5cf37535941 136bad5cf58d_   Termination of Normal Unintended Pregnancy

8.   _cc781905-5cde-3194-bb3b-136bad5bb-136bad5cf1365c3593194-bb3b-136bad5bb5cf1365c3593194-bb3b-136bad5bb-136bad5cf3b-136bad359cf1365cdebbc-3194cf781905cc783194 136bad5cf58d_   Termination of Abnormal Pregnancy (Mumped fetus, fetal membrane hydrops, dead fetus)

9.   _cc781905-5cde-3194-bb3b-136bad5cf-136bad5cf1365cf83194cc781905-5cde-3194-bb3b-136bad5bb-136bad5cf1365c35931cc781905-5cf5835941 136bad5cf58d_   Chronic Endometritis and Pyometra

10.   _cc781905-5cde-3194-bb3b-136bad5cf_58358cc19-cc781905-5cde-3194-bb3b-136bad5cf_58358cc19-bb3b-136bad5cf315359cc781905cf359434343434343d 136bad5cf58d_ Postpartum Metropathy and Uterine Involution

11.   _cc781905-5cde-3194-bb3b-136bad5cf-136bad5cf1365cf583194-bb3b-136bad5cf5cf5cf583194-bb3b-136bad5cf1365cdebbcf5cf1365cf583194 136bad5cf58d_ Synchronization of donor and recipient sexual cycles in the Early Embryo Transfer Program in Cattle.

In mares:

1.   _cc781905-5cde-3194-bb3b-136bad5cf-136bad5cf1365cf3593194-bb3b-136bad5cf1365cdebbcf5cf1365cf583194-cc781905-5cde-3194-bb3b-136bad5bb-136bad5cf1365c35931cc781905-5cf5831944_cc781905-5cde-3194-cc781905-5cde-3194. 136bad5cf58d_   Estrus Sync

2.   _cc781905-5cde-3194-bb3b-136bad5cf-136bad5cf5cf5cf583194-bb3b-136bad5bbcf1365c3593194-bb3b-136bad5bbcf1365c3593194 136bad5cf58d_   Termination of False Pregnancy

3.   _cc781905-5cde-3194-bb3b-136bad5cc-136bad5cf3b-136bad5cf5cf5cf583194-bb3b-136bad5bcf1365c3593194-bb3b-136bad5bbcf375c375378 136bad5cf58d_   Anestrus Treatment in Lactation

4.   _cc781905-5cde-3194-bb3b-136bad5cf-136bad5cf5cf5cf583194-bb3b-136bad5bbcf1365c3593194-bb3b-136bad5bb5cf1365c35931cc781905-5cde-3194-bb3b-136bad5bb-136bad5cf1365c35931-cc781905-5cde- 3194 136bad5cf58d_   Persistent Corpus Luteum and Calm Anger

5.   _cc781905-5cde-3194-bb3b-136bad5bb-136bad5cf1365c3593194-bb3b-136bad5bbcf1365c3593194-bb3b-136bad5cf5cf5cf359cf1365359378 136bad5cf58d_   Prolonged Diestrus

6.   _cc781905-5cde-3194-bb3b-136bad5bb-136bad5cf1365c3593194-bb3b-136bad5bbcf1365c3593194-bb3b-136bad5bb5cf1365cf3593194-bb3b-136bad5bb5cf1365c3593194 136bad5cf58d_   Birth Initiation

In Pigs:

Birth Initiation

In cows:

Oestrus Provocation and Synchronization:

First the corpus luteum is detected (between the 6th and 14th days of the cycle) 2 ml of ESTROPUR (= 0.15 mg of active ingredient) is applied and insemination is done 70-120 hours after the application, based on the developing oestrus symptoms. If estrus does not develop, the application is repeated 11 days after the first application.

Treatment of Ovarian Functional Disorders:

After the corpus luteum is determined, ESTROPUR is applied, insemination is done at the first oestrus that occurs. If estrus has not developed, the application is repeated 11 days later.

Postpartum or Postmating Anestrus:

After the corpus luteum is detected, ESTROPUR is applied, insemination is done at the first oestrus that occurs. If estrus has not developed, the application is repeated 11 days later.

Combined Treatment of Luteal Cysts and Follicular Cysts:

Here, the treatment is carried out in combination with GnRH or HCG (Human Coriogonodotropin). If a positive response is obtained from the ovaries after the administration of GnRH or HCG, ESTROPUR is administered 10-14 days after the administration.

Subestrus (latent or quiescent estrus):

In these animals, the ovary is actually active and there is a cycle, but the signs of estrus are invisible or not noticeable because they are mild. In these animals, after detecting the corpus luteum by rectal palpation, ESTROPUR is administered, insemination is performed at the first oestrus that occurs. If estrus has not developed, the application is repeated 11 days later.

Birth Initiation:

In cases of healthy pregnancy for different reasons, ESTROPUR is applied after the 270th day of pregnancy to give birth.

Termination of Unwanted Normal Pregnancy:

ESTROPUR is used to terminate pregnancy in very young or immature animals that mate accidentally, become pregnant from an unwanted bull or are unable to terminate their pregnancy in a healthy way.

However, ESTROPUR should be used earlier than the 150th day of pregnancy. Because after the 150th day, placental progesterone kicks in and makes the pregnancy less dependent on the corpus luteum. Therefore, results may not be obtained from the application.

While abortion is successfully achieved in the first 100 days of pregnancy, 100-150. days, less success is achieved for the reason stated. This application should not be done after the 150th day.

ESTROPURAnimals usually abort within 3-5 days following administration. If abortion has not occurred, a second application can be made.

Animals undergoing abortion should be kept under surveillance until the baby membranes and fetus are expelled, attention should be paid to infections that may occur after abortion, care and nutrition should be taken care of.

Termination of Abnormal Pregnancy (Mumified fetus, fetal membrane hydrops, dead fetus)

Mumified Fetus:

With the death of the fetus, dehydration and degeneration begin and the fetus becomes mummified. In such a case, ESTROPUR is used at any time of pregnancy to expel the mummified fetus. In cases where the fetus is not expelled from the vagina, it is taken from the outside by manual intervention. After expulsion, the normal cycle continues.

Hydrops of Fetal Membranes:

The fetus dies due to complications that occur as a result of pathological accumulation of placental fluids. In cases where operative drainage is not successful, abortion is created with the application of ESTROPUR. In such cases, ESTROPUR is administered as a single dose. For intervention to be successful, it should be done as early as possible.

Chronic Endometritis and Pyometra:

In the postpartum period, endometritis due to uterine infections and Pyometra events are encountered as this event progresses and becomes pus. In the presence of pyometra, oestrus is suppressed and a permanent corpus luteum is formed. In such cases, the use of ESTROPUR in addition to the application of local and systemic antibiotics will increase the success.

ESTROPURThe principle of the therapeutic action of Endometritis or Pyometra; you are in estrus with luteolysis

The onset of pregnancy is an increase in uterine motility, which, together with the mobilization of protective agents in the endometrium, causes expulsion of unwanted uterine contents.

Postpartum Metropathy and Uterine Involution:

In such cases, a single dose or, if necessary, a second dose of ESTROPUR can be used.

The sexual cycle of donors and recipients in the Early Embryo Transfer Program in Cattle

sync:

ESTROPURIn embryo donors, it is administered on the 3rd day after the superovulation preparation is started (2 ml in the morning, 2 ml in the evening)

In mares:

Oestrus Synchronization:

ESTROPUR is administered twice, with an interval of 14 days, on the 19th and 21st days, although no signs of oestrus are observed.

is seeded.

Termination of False Pregnancy:

ESTROPURThose who show clinical signs of pregnancy after the estrous cycle, even though they are not pregnant

To eliminate the phenomenon of False Pregnancy in animals and to normalize ovarian functions.

used to rotate.

Anestrus Treatment in Lactation:

To correct this situation in mares who do not show estrus again in the postpartum period,

ESTROPURused.

Persistent Corpus Luteum and Calm Anger:

In the presence of a permanent corpus luteum or in mares that do not show signs of oestrus despite the cycle

ESTROPURused.

Prolonged (Stubborn) Diestrus:

Non-pregnant mares, especially late in the breeding season, may experience frequent or full estrus.

They enter an irregular period of diestrus in which they do not show symptoms. In this case, the mares have a long

are in the diestrus stage. ESTROPUR is applied to such animals within 2-8 days.

estrus is ensured.

Birth Initiation:

If necessary, after the 320th day of pregnancy, ESTROPUR can be applied within a few hours.

birth is possible.

In Pigs:

A single dose of 1 ml of ESTROPUR is administered to induce labor in sows.
It is administered intramuscularly.      _cc781905-5cde-3194-bb3b-136bad-136bad5cf3b-136d58359cf1365cf583594cc781905-5cde-3194-bb3b-136bad-136bad5cf1365cf78359cc1365359cc58359cf1365cde78359cc78195 5cde-3194-bb3b-136bad5cf58d_

In cows:      _cc781905-5cde-3194-bb3b-3194-bb359359cf369359cf34359cbdc_cc781904 136bad5cf58d_      _cc781905- 5cde-3194-bb3b-136bad5cf58d_   _cc7819__fcf5831994b-3194-bb3b-136bad5cf58d__cc7819__fcf583153b-cc7819__fbcf313358b-3194-bb3b-136bad5cf58d__cc7819__fbcf31335831 150mg)/day

In mares:      _cc781905-5cde-3194-bb3b-b-136bad578c531365 136bad5cf58d_      _cc781905- 5cde-3194-bb3b-136bad5cf58d_   1 ml (75mg)/day

In Female Pigs:      _cc781905-5cde-3194-cc781905-bb394__cfcf583194-bb394__ccf583195cf58d__cc781905-5cde-3194-cf359359-bb394_cf3753594c -136bad5cf58d_ 1 ml (75mg)/day
It should not be used intravenously. In mares with acute or sub-acute disorders of the gastrointestinal tract, in mares with acute or sub-acute respiratory disease (this is an important criterion because in some animal species injection of prostaglandins can result in acute respiratory problems), death due to rupture of the uterus in the absence of cervical dilatation should not be used as it can be seen.

Use in Pregnancy:Luteolysis during some periods of pregnancy can lead to fetal loss. For this reason, it is not used in pregnant cows and mares, except in cases of unwanted pregnancies and involuntary birth in the last period of pregnancy.

Estropur

Target Species

Pharmacological Properties

Positioning

Usage Area and Indications

Usage and Dosage

Contraindications